Personal:
I am a postdoctoral research fellow
in Dr. Bisht's group working on the
synthesis
of biologically active
compounds and Enzymatic synthesis
of Macromolecules.
I am from the state of Andhra Pradesh in
India. I was born at Narsapuram, W.Godavari District a beautiful place with picturesque landscape full of paddy
fields and coconut trees on the banks of river Godavari in coastal Andhra.
I was brought up in Hyderabad, capital city of Andhra Pradesh. Hyderabad, also known as
Cyberabad is one of the fastest growing cities in India with a population of about 5 million. The city is highly cosmopolitan, and is endowed with a variety
of cultures and presents an attractive amalgamation of ancient architecture
together with modern developments. The history of Hyderabad begins with the formation of the Qutub Shahi dynasty, Mohammed Quli Qutub Shah, the Fifth king
of Golconda, founded this city in 1591 by laying the foundation of the famous monument
'Charminar' as the center of the city.
Education:
I did my BS (1991, Chemistry Major) and MS (1993, Organic Chemistry) from Osmania University
-Hyderabad, the largest University in the state of Andhra Pradesh with more than 150,000
students.
The main campus is spread over in an area of about 1200 acres with seven
colleges. It has several off campus centers along with 400 government & private colleges affiliated to it.
The university has more than 1100 teaching faculty and about 3000 non-teaching staff on
its rolls. There are 9 faculties in the University & sixty departments offering diversified
subjects at the undergraduate & postgraduate levels, besides research , doctoral & postdoctoral
programs in various disciplines. The University has also established several centers of
excellence in Science, Engineering & other areas of human concern.
I did my Ph.D. (2000) in Organic Synthesis at Indian Institute of Chemical Technology
under the supervision of Dr. J. Madhusudana Rao, Former Head, Org-II division, IICT
and was awarded doctorate in May 2000 on " Synthesis of fluorosubstituted alkenes
and their cycloaddition reactions " by Osmania University.
IICT a National Laboratory and a constituent of Council of Scientific & Industrial
Research (CSIR), is a premier R&D Institute in India. Established in 1944, the Institute
has made significant contributions in the field of Chemical Sciences and Technology. Major
areas of research are agrochemicals, drugs, organic intermediates, oils and fats, organic
coatings and polymers, catalysis, coal chemical engineering and design & engineering.
PROJECTS UNDERTAKEN:
Presently working on the synthesis of Biologically active compounds to develop novel anticancer and
anti-fungal drugs and
in the biosynthesis of macromolecules which find application as biodegradable polymers
for biomedical applications.
Worked as a research fellow at Indian Institute of Chemical Technology,
Hyderabad, India since Jan 1994 - April 2000
a) For the doctoral work I took up the synthesis of several novel fluoro dienophiles
starting from simple fluoro olefins and their cycloaddition reactions with dienes such
as cyclopentadiene, furan and 1,3diphenyl iso benzofuran were studied. The work was
aimed at the study of reactivity, stereoselectivity and also to synthesize new
fluoroorganics. The novel fluoro cycloadducts thus synthesised are valuable synthons for developing new
antiviral compounds.
b) AlF3 is an active catalyst and support in dismutation, halogen exchange and dehydrohalogenation reactions. Different phases of AlF3 were prepared by new route and dismutationreactions of CFC's and HFC's on different forms of catalyst prepared were stud
ied as a
model reaction to evaluate the reactivity of these forms in halogen exchange reactions.
These studies led to the development of an efficient catalyst for the development of
technology for HFC-134a. The results of these studies were patented. (CSIR-India). Part of the results were published in J. Catal. and J.Fluorine. Chem.
APPLIED WORK
a)TECHNOLOGY FOR HFC-134a (Sponsored by DST, New Delhi and M/s. SRF &
NFI,India). Involved in active research project dealing with the development of technology for
HFC-134a (1,1,1,2-tetra fluoroethane) a widely recommended substitute for ozone depleting
chlorofluoro carbons, which are used as refrigerants. The study involves optimisation ofcatalyst,
pressure, temperature, contact time, moleratio and catalyst life for the two-stagetechnology. The technology was developed on bench scale and successfully
demonstrated to the sponserers.
b)TECHNOLOGY FOR CFC 113a (Sponsored by Ms. SEARLE,India)
Technology for113a (1,1,1-trichloro-2,2,2-trifluoroethane) an important intermediate
for several biologically active molecules and industrial lubricant was developed and
demonstrated on bench scale.
PUBLICATIONS and PATENTS
1.Synthesis and Diels-Alder cycloaddition reactions of [(2,2-dichloro-1- fluoroethenyl
sulfinyl) benzene] and [(2-chloro-1,2-difluoroethenyl sulfinyl) benzene] M. Sridhar K. Leela Krishna and
J.M. Rao. Tetrahedron , 56, 3539, 2000.
2.Microwave activated Diels-Alder cycloaddition reactions of 1,2-difluoro-1-chlorovinyl
phenylsulfone. M. Sridhar, K. Leela Krishna, K. Srinivas andJ.Madhusudana Rao,
Tetrahedron Lett., 39, 6529, 1998
3. A facile synthesis of 2(H)-oxo-3-substituted-1-benzo pyrans. K.Srinivas, K.Leela Krishna,A.Siva prasad and P.Shanthan
Rao, Indian J. Chem., 37B, 936, 1998
4 .A comparative study of bulk and supported chromia catalyst on the fluorination oftrichloroethylene.
J.M.Rao, A.Siva Prasad, P.Shanthan Rao, B.Narsaiah, S.N.Reddy,V.V.Kumar,
S.V.Manorama, K.Leela Krishna, K.Srinivas, K.Radhakirshnan and S.Badrinarayanan.
J. of Catalysis 184, 105, 1999
5.Effect of acid strength of coprecipitated chromia/alumina catalyst on the conversion and
selectivity in the fluorination of 2-chloro-1,1,1-trifluoro ethane to1,1,1,2-tetrafluoroethane J.M.Rao, P.Shanthan Rao, V.V.Kumar, V.V.Rao, B.Narsaiah, S.N.Reddy, K. Leela Krishna,
K. Srinivas, K. Radhakrishnan and K.S. Patil, J. of Fluorine Chemistry 95, 177, 1999
6. A process for the preparation of 2-oxo (2H)-1-benzopyran (coumarins) (Indian Patent) No 5350: 663/DEL/1996
P. Shanthan Rao, K. Srinivas, K. Leela Krishna and A. Siva Prasad.
7. A Process for the preparation of 2-chloro-1,1,1-trifluoro ethane (HCFC-133a, an intermediate for HFC-134a)
Indian IN 61/DEL/99 J.M. Rao, P. Shanthan Rao, A. Siva Prasad, B. Narsaiah, S.N.Reddy, K. Radhakrishna,V.V.
Kumar,
K.S. Patil, Y. Rambabu, K.Srinivas and K. Leela Krishna.
8. A process for the preparation of 1,1,1,2-tetrafluoroethane (HFC-134a, a widely
recommended substitute for chloro fluoro carbons) Indian IN (1998) 62/DEL/99 J.M. Rao, P. Shanthan Rao, A. Siva
Prasad, B. Narsaiah, S.N. Reddy,K.Radhakrishna, V.V. Kumar,
K.S. Patil, Y. Rambabu, K.Srinivas and K. Leela Krishna.
